In Vitro Metabolism of Dehydroepiandrosterone and Testosterone by Canine Hair Follicle Cells

    February 2004 in “ Veterinary Dermatology ”
    E. Bamberg, Amanda Aichinger, Gerda Mitteregger
    TLDR Canine hair follicle cells metabolize DHEA and testosterone differently than human cells.
    The study investigated the in vitro metabolism of dehydroepiandrosterone (DHEA) and testosterone in dermal papilla cells (DPC) and dermal fibroblasts (DFB) from hair follicles of four male, castrated beagle dogs. It was found that DHEA was primarily metabolized to 11α-OH-testosterone, with the highest metabolization occurring in DFB from the head. Testosterone was minimally metabolized to 5α-dihydrotestosterone and epiandrosterone, with no significant differences between cell types or body locations. The findings indicated that androgen metabolism in canine hair follicle cells differed from that in human hair follicle cells.
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