Biological, Cellular, And Molecular Characteristics Of An Inducible Transgenic Skin Tumor Model: A Review
December 2005
in “
Oncogene
”
Research cited in this study
3 / 3 resultsresearch Enrichment for Living Murine Keratinocytes from the Hair Follicle Bulge with the Cell Surface Marker CD34
561 citations , April 2003 in “Journal of Investigative Dermatology” CD34 is a marker for isolating stem-like cells in mouse hair follicles.
research Co-Operation Between Follicular Ornithine Decarboxylase and v-Ha-ras Induces Spontaneous Papillomas and Malignant Conversion in Transgenic Skin
88 citations , August 1998 in “Carcinogenesis” High levels of ODC and a mutant Ha-ras gene cause tumors in mice.
research Expression of the Bcl-2 Proto-Oncogene in the Cycling Adult Mouse Hair Follicle
122 citations , July 1994 in “Journal of Investigative Dermatology”Related Community Posts Join
6 / 1000+ resultscommunity Is it possible to transplant mice skin into human body?
in Transplants 47 upvotes 5 months ago Transplanting mice skin to humans is not feasible due to immune rejection, but some suggest genetic modification or immune suppression could make it possible. Xenograft hair transplants are discouraged.
community Seeking Suggestions for VEGF Gene Therapy in Hair Transplants
in Basic Questions 75 upvotes 6 days ago A user is exploring VEGF gene therapy to enhance hair transplant results, considering measuring hair shaft diameter and growth rate. Suggestions include using phototrichograms and possibly adding PRP, though its effectiveness is uncertain.
community Hair Multiplication Projects in China - Promising clinical trial results on Mice
in Technology 35 upvotes 10 months ago A breakthrough in hair follicle cultivation using induced pluripotent stem cells (iPSCs) has been achieved, producing large hair follicles suitable for transplantation. Clinical trials for this hair multiplication technology are planned in partnership with Yinguan Biotechnology.
community Anagenic is trying to compound Gt20029
in Treatment 55 upvotes 3 years ago The conversation discusses concerns that Anagenic's version of GT20029 might not be as effective or safe as Kintor's, with comparisons to issues faced by pyrilutamide. The chemical structure of the drug has been published.
community TGF-Beta. Good or Bad? Help for treatment investment
in Treatment 12 upvotes 3 years ago TGF-B affects hair growth, both causing stem cell division and death depending on amounts. Amplifica's treatment injects Scube3 to increase TGF-B for hair growth.
community Functional hair follicles grown from stem cells: Scientists have created natural-looking hair that grows through the skin using human induced pluripotent stem cells (iPSCs), a major scientific achievement that could revolutionize the hair growth industry.
166 upvotes 6 years ago Scientists have grown natural-looking hair from stem cells, potentially revolutionizing hair growth treatments. Concerns include cost, DHT resistance, and the need for future procedures.
Similar Research
5 / 1000+ resultsresearch Overexpression of insulin-like growth factor-1 induces hyperplasia, dermal abnormalities, and spontaneous tumor formation in transgenic mice
147 citations , April 1997 in “Oncogene” Overexpressing IGF-1 in mice leads to skin abnormalities and tumors.
research Reconstitution of human skin in vitro using readily available sources: Novel studies of tumour promotion
August 1994 in “Toxicology in Vitro” A lab model of human skin was created to study skin tumor promoters without using actual human skin.
research Basement Membranes in Experimentally Induced Skin Tumors
8 citations , August 1986 in “Journal of Investigative Dermatology”research Induction of basal cell carcinomas and trichoepitheliomas in mice overexpressing GLI-1
333 citations , March 2000 in “Proceedings of the National Academy of Sciences” Overexpressing GLI-1 in mice skin can cause tumors like human basal cell carcinomas.
research Cutaneous Two-Stage Chemical Carcinogenesis
1 citations , December 2014 in “Zenodo (CERN European Organization for Nuclear Research)” The method effectively induces skin cancer in mice for studying tumor development.