Infectious Events in Patients With Alopecia Areata Treated With JAK Inhibitors: Low Burden and Minimal Impact on Persistence in Treatment

    May 2024 in “ Expert Opinion on Drug Safety ”
    Giacomo Caldarola, Lorenzo Maria Pinto, Francesco Bellinato, Nicoletta Bernardini, Elena Campione, Andrea Chiricozzi, Laura Colonna, Clara De Simone, Laura Diluvio, Paolo Gisondi, Enrico Matteini, Eleonora Tomassetti, Ersilia Tolino, Luca Bianchi, Ketty Peris
    TLDR Infections during JAK inhibitor treatment for alopecia areata are usually manageable and rarely stop treatment permanently.
    A retrospective study involving 91 alopecia areata patients treated with JAK inhibitors found that 34 infectious events occurred in 28 patients (30.8%). Despite these events, only one patient permanently discontinued treatment, while 17 patients temporarily suspended it until the infection resolved. The study concludes that infectious events during JAK inhibitor treatment are generally manageable and rarely lead to permanent discontinuation, aligning with previous clinical trial findings.
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