Therapeutic Inhibition of Keratinocyte TRPV3 Sensory Channel by Local Anesthetic Dyclonine

The study investigated the therapeutic potential of dyclonine, a local anesthetic, in inhibiting the TRPV3 sensory channel, which is expressed in epidermal keratinocytes and associated with skin disorders such as chronic pruritus and hair growth issues. The research demonstrated that dyclonine effectively inhibited both mouse and human TRPV3 channels, rescuing cell death caused by gain-of-function TRPV3 mutations and reducing pruritus symptoms in a mouse model. The study also identified specific residues in the TRPV3 pore region that influence dyclonine's inhibitory efficiency, providing insights that could aid in developing new treatments for skin inflammation.