An Injectable Photocuring Silk Fibroin-Based Hydrogel for Constructing an Antioxidant Microenvironment for Skin Repair

    January 2024 in “ Journal of Materials Chemistry B ”
    Tangjinhai Liu, Yuxiang Wang, Jingyi Liu, Xiaowen Han, Yaping Zou, Peilei Wang, Ruiling Xu, Lei Tong, Jun Liu, Jie Liang, Yong Sun, Yujiang Fan, Xingdong Zhang, Yujiang Fan, Xingdong Zhang
    TLDR The hydrogel speeds up wound healing and improves skin repair better than commercial options.
    The study presents an injectable photocuring silk fibroin-based hydrogel (SF-g-SDA) designed to create an antioxidant microenvironment for skin repair. This hydrogel incorporates methacrylated dopamine into methacrylated silk fibroin, resulting in a material with excellent tensile and adhesion properties, stable mechanical properties, biodegradability, and cytocompatibility. It promotes cell adhesion, vascularization, and protects cells from oxidative stress. In animal experiments, SF-g-SDA outperformed commercial Tegaderm™ by accelerating wound healing, enhancing collagen deposition and alignment, and promoting neovascularization and hair follicle formation, indicating its potential as an effective wound dressing.
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