TLDR Innovative biomaterials show promise in healing chronic diabetic foot ulcers.
The document reviews the development and potential of innovative functional biomaterials as therapeutic wound dressings for chronic diabetic foot ulcers (DFUs). It highlights the significant burden of DFUs and the need for advanced treatment options. Various natural and synthetic biomaterials, such as alginate, cellulose, chitosan, collagen, dextran, fibrin, hyaluronic acid, polycaprolactone, and polyethylene glycol, are evaluated for their properties and effectiveness in promoting wound healing. These materials show promise in enhancing angiogenesis, reducing inflammation, and providing antibacterial activity, thereby improving the healing process in diabetic models. Some formulations are also under clinical trials, indicating their potential for future clinical application.
18 citations
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April 2022 in “Frontiers in bioengineering and biotechnology” Gelatin microspheres with stem cells speed up healing in diabetic wounds.
110 citations
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April 2020 in “Advances in Wound Care” Nanotechnology shows promise for better chronic wound healing but needs more research.
1160 citations
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November 2018 in “Physiological Reviews” The document concludes that better targeted treatments are needed for wound healing, and single-cell technologies may improve cell-based therapies.
2 citations
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June 2023 in “Pharmaceutics” Nanofiber scaffolds help wounds heal by delivering drugs directly to the injury site.
10 citations
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November 2015 in “Elsevier eBooks” Modern wound dressings like hydrocolloids, alginates, and hydrogels improve healing and are cost-effective.
30 citations
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February 2022 in “Pharmaceutics” 3D bioprinting improves wound healing by precisely creating scaffolds with living cells and biomaterials, but faces challenges like resolution and speed.
July 2023 in “International Journal of Cosmetic Science” Biopolymers are increasingly used in cosmetics for their non-toxicity and skin benefits, with future biotech advancements likely to expand their applications.
83 citations
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June 2020 in “Materials & Design” Sponge helps heal wounds faster with less inflammation and better skin/hair growth.
