Integrated Multi-Omics Analysis Reveals Dysregulated Lipid Metabolism as a Novel Mechanism in Androgenetic Alopecia

The study identifies dysregulated lipid metabolism as a novel mechanism in androgenetic alopecia (AGA) through a multi-omics approach involving seven male subjects. It reveals significant changes in lipid metabolism-related pathways, such as the PPAR signaling pathway and steroid biosynthesis, with genes like ACAA1 and PEX3 upregulated and IDH1 downregulated in scalp tissues. The research highlights the role of ACAA1 and hsa-miR-1343-3p in regulatory mechanisms, suggesting potential therapeutic targets within lipid-related pathways. Despite its insights, the study acknowledges limitations due to the small sample size and calls for further validation through larger cohorts.