Impact of Intermittent Fasting on Insulin Sensitivity and HbA1c Levels Among Overweight Adults with Prediabetes

The study evaluated the effects of a 12-week intermittent fasting regimen on insulin sensitivity and HbA1c levels in 42 overweight adults with prediabetes, with 38 completing the study. Participants followed a 16-hour fasting window daily. Results showed significant improvements: fasting glucose decreased from 111.6 to 102.3 mg/dL, fasting insulin from 15.9 to 12.8 µIU/mL, HOMA-IR from 4.37 to 3.23, and HbA1c from 6.05% to 5.78%, all with p < 0.001. The findings suggest intermittent fasting as a practical, low-cost strategy to delay type 2 diabetes progression, though larger trials are recommended.