Exploring the Interplay Between Arsenic and Cutaneous Physiology, Pathology, and Regeneration

    November 2023 in “ IntechOpen eBooks ”
    Mangalathettu Binumon Thankachan, Gayathri S. Kamath, Greeshma Sasikumar, Sreejith Parameswara Panicker
    TLDR Arsenic exposure from contaminated water severely damages the skin, causing hair loss, pigmentation changes, irritation, and can lead to skin cancer.
    The document "Exploring the Interplay between Arsenic and Cutaneous Physiology, Pathology, and Regeneration" discusses the significant health hazards posed by arsenic exposure, particularly through contaminated drinking water. Chronic exposure leads to various skin conditions, including hyperpigmentation, keratosis, and skin cancers like basal cell carcinoma and Bowen’s disease. The document highlights the biochemical processing of arsenic in the liver, its systemic effects such as oxidative stress and DNA damage, and the need for reliable biomarkers to assess exposure. It underscores the importance of effective management strategies, such as avoiding contaminated water and using alternative sources, to mitigate arsenic toxicity.
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