Interventions for Central Serous Chorioretinopathy: A Network Meta-Analysis

This network meta-analysis reviewed 67 randomized controlled trials involving 4015 participants to assess the effectiveness of various interventions for central serous chorioretinopathy (CSC). The study found no significant evidence favoring one treatment over another, with low-dose photodynamic therapy, supplements, and eplerenone showing the highest probabilities of being the best treatments for improving visual acuity according to SUCRA analysis. However, the confidence in these findings is low to moderate due to biases, small sample sizes, and poor reporting in many trials. The authors conclude that CSC remains a challenging condition to treat effectively, and larger, high-quality trials are needed to establish more definitive treatment guidelines.