Intraoperative Iris Behavior During Phacoemulsification Maneuvers in Rabbits Treated with Selective Alpha-1 Blocker, 5-Alpha-Reductase Inhibitor, or Anxiolytic Medication

This study evaluated the impact of tamsulosin, finasteride, and lorazepam on intraoperative iris behavior during phacoemulsification in 31 rabbits. The results indicated that tamsulosin (OR = 8.33), finasteride (OR = 11.6), and lorazepam (OR = 7.5) significantly increased the risk of intraoperative floppy iris syndrome (IFIS) compared to the control group. These findings suggest that these medications can alter iris behavior during cataract surgery, potentially leading to complications, and highlight the importance of preoperative documentation of these medications.