Invasive Giant Pituitary Macroadenoma Causing Cushing Disease: A Case Report

This case report described a 41-year-old female with Cushing disease caused by a rare giant pituitary macroadenoma. The patient presented with symptoms including unintentional weight loss, polyuria, polydipsia, facial changes, frontal balding, and increased abdominal size. She also exhibited hirsutism, male pattern hair loss, and generalized skin thinning. Despite undergoing transcranial surgery, the procedure was unsuccessful due to intraoperative bleeding, necessitating postoperative radiotherapy. The report concluded that giant pituitary macroadenomas causing Cushing disease are rare and may require additional therapeutic measures if surgery fails.