Is There a Role for Sodium Fluoride in Otosclerosis Treatment?

The paper evaluates the role of sodium fluoride (NaF) in managing otosclerosis, a condition that can lead to hearing loss. While some studies suggest NaF may slow or halt sensorineural hearing loss (SNHL) in otosclerosis patients, there is no consensus or established guidelines for its use. A study involving 192 patients showed NaF benefited those with active otospongiotic processes, while another study with 50 patients found improved hearing post-treatment. However, evidence supporting NaF's efficacy is weak, with concerns about study biases and potential side effects, including hair loss and fluorosis. The paper calls for larger, randomized studies to better understand NaF's benefits and risks, emphasizing caution due to potential toxicity and the availability of alternative treatments like cochlear implants.