<i>signatureSearch</i>: environment for gene expression signature searching and functional interpretation
September 2020
in “
Nucleic Acids Research
”
TLDR The package helps analyze and interpret gene expression data by comparing it to a database of conditions.
The signatureSearch R/Bioconductor package provided an integrated environment for gene expression signature searching and functional enrichment analysis, facilitating the interpretation of gene expression data. It allowed users to search a query gene expression signature against a database of signatures from various conditions, such as genetic backgrounds and drug perturbations, to identify related cellular responses. The package included novel algorithms and visualization tools to highlight modulated processes and network connections, making it useful for studying genetic, chemical, and environmental impacts on biological systems. It also supported custom databases, enhancing its utility for diverse research applications.
