Isoginkgetin, A Natural Biflavonoid From Ginkgo Biloba, Inhibits Inflammatory Response In Endothelial Cells Via Suppressing NF-κB Activation

Isoginkgetin (ISOGK), a biflavonoid from Ginkgo biloba, has been shown to inhibit inflammatory responses in endothelial cells by suppressing NF-κB activation. This compound, first isolated in 1983, is known for its antioxidative and antitumor properties. ISOGK activates the NRF2/ARE pathway, enhancing the expression of protective enzymes like HO-1 and NQO1, which mitigate oxidative damage and improve mitochondrial function in cardiomyocytes. Additionally, ISOGK acts as a spliceosome inhibitor, affecting tumor gene expression and inducing cytotoxic effects. Its potential anti-inflammatory activity, particularly in the context of endothelial inflammation, adds to the therapeutic promise of ISOGK in various medical applications.