Effects of Isotretinoin on Body Mass Index, Serum Adiponectin, Leptin, and Ghrelin Levels in Acne Vulgaris Patients

    January 2016 in “ Advances in Dermatology and Allergology ”
    Bengü Çevirgen Cemil, Havva Hilal Ayvaz, Gülfer Öztürk, Can Ergin, Havva Kaya Akış, Müzeyyen Gönül, Ercan Arzuhal
    TLDR Isotretinoin may reduce inflammation by increasing adiponectin and leptin levels.
    This study investigated the effects of isotretinoin on BMI and serum levels of adiponectin, leptin, and ghrelin in 32 acne vulgaris patients. The results showed that isotretinoin treatment did not significantly change BMI or serum ghrelin levels. However, there was a significant increase in serum adiponectin and leptin levels after treatment. The study concluded that isotretinoin might exert its anti-inflammatory effects by increasing these levels.
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