Comparison of In Vitro Fertilization/Intracytoplasmic Sperm Injection Cycle Outcome in Patients with and without Polycystic Ovary Syndrome: A Modified Poisson Regression Model

In a historical cohort study at the Royan Institute in Tehran, Iran, involving 996 infertile women, researchers investigated the impact of polycystic ovary syndrome (PCOS) on the success of assisted reproductive treatment (ART) using a modified Poisson Regression model. Initially, unadjusted analysis showed a lower risk of ART failure in women with PCOS, but after adjusting for confounders like age, treatment protocol, and number of embryos transferred, the difference in non-pregnancy risk between women with and without PCOS was not significant. The study concluded that PCOS does not significantly affect the risk of non-pregnancy in ART patients, and that other factors are likely influential in conception outcomes for PCOS patients. The study also highlighted the need for future research to include long-term follow-up on pregnancy complications and outcomes in newborns from IVF/ICSI, especially in women with PCOS.