JAK Inhibitors in the Treatment of Lichen Planopilaris

November 2023 in “ Skin Appendage Disorders ”

Maryam Nasimi, Mahshid Sadat Ansari

JAK inhibitors Lichen Planopilaris Frontal Fibrosing Alopecia

TLDR JAK inhibitors might help treat Lichen Planopilaris, but more research is needed.

JAK inhibitors are emerging as a potential new therapeutic option for treating Lichen Planopilaris (LPP) and Frontal Fibrosing Alopecia (FFA), particularly in cases that are resistant to other treatments. However, the current data supporting their use is limited to retrospective studies and case reports, indicating a need for further research to establish their efficacy and safety in these conditions.

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Research cited in this study

10 / 10 results

research Baricitinib as an Effective Treatment for Lichen Planopilaris

2 citations , October 2022 in “Dermatologic Therapy”

Baricitinib may effectively treat lichen planopilaris.

research Frontal Fibrosing Alopecia: A Review

23 citations , April 2021 in “Journal of Clinical Medicine”

Frontal Fibrosing Alopecia's cause is unclear, affects mainly postmenopausal women, and current treatments focus on stopping hair loss rather than regrowth.

research Hair Loss in Lichen Planopilaris and Frontal Fibrosing Alopecia: Not Always Irreversible

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Hair loss from conditions like LPP and FFA can potentially be reversed with the right treatment.

research Frontal Fibrosing Alopecia: An Update on the Hypothesis of Pathogenesis and Treatment

38 citations , January 2019 in “International Journal of Women's Dermatology”

The document concluded that more research is needed to find the best treatment for Frontal fibrosing alopecia.

research Frontal Fibrosing Alopecia: An Update on Pathogenesis, Diagnosis, and Treatment

61 citations , January 2019 in “American Journal of Clinical Dermatology”

The cause of Frontal Fibrosing Alopecia is unclear, diagnosis involves clinical evaluation and various treatments exist, but their effectiveness is uncertain.

research JAK-Inhibitors in Dermatology: Current Evidence and Future Applications

45 citations , November 2018 in “Journal of dermatological treatment”

JAK-inhibitors are effective for treating psoriasis and show promise for other skin diseases.

research Lichen Planopilaris: Retrospective Study on the Characteristics and Treatment of 291 Patients

48 citations , November 2018 in “Journal of dermatological treatment”

Women are more likely to have Lichen planopilaris, and treatments with cyclosporine and methotrexate are most effective but less safe than mycophenolate mofetil.

research Tofacitinib for the Treatment of Lichen Planopilaris: A Case Series

79 citations , September 2018 in “Dermatologic therapy”

Oral tofacitinib can significantly improve recalcitrant lichen planopilaris.

research JAK Inhibitors in Dermatology: The Promise of a New Drug Class

355 citations , January 2017 in “Journal of the American Academy of Dermatology”

JAK inhibitors show promise for treating skin conditions like eczema, hair loss, and psoriasis.

research Treatment of Frontal Fibrosing Alopecia and Lichen Planopilaris: A Systematic Review

117 citations , March 2013 in “Journal of the European Academy of Dermatology and Venereology”

No effective treatment for frontal fibrosing alopecia was found, but oral 5-alpha-reductase inhibitors had the best response; for lichen planopilaris, topical corticosteroids were commonly used but had a high relapse rate.

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