Janus Kinase Inhibitors in Dermatology: A Review

    January 2023 in “ Portuguese Journal of Dermatology and Venereology ”
    Bárbara Vieira-Granja, Sofia Magina
    TLDR JAK inhibitors effectively treat skin conditions and topical forms are safer.
    Janus Kinase (JAK) inhibitors were found to be effective in treating various immune-related dermatological conditions, including atopic dermatitis, alopecia areata, psoriasis, and vitiligo, by blocking cytokine functions and gene transcription related to inflammation and immunity. While oral administration of JAK inhibitors was common, concerns about side effects led to the exploration of topical formulations, which appeared to be safe, well-tolerated, and a promising alternative.
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