Engineered Janus Hydrogels: Biomimetic Surface Engineering and Biomedical Applications

Janus hydrogel bioadhesives, with their asymmetric surface designs, offer a promising solution to the limitations of traditional hydrogel bioadhesives used in medical applications. These engineered hydrogels mimic natural biological barriers, providing robust tissue integration and serving as effective anti-adhesion, anti-fouling, and anti-wear barriers. This review outlines the design principles and engineering methods for Janus hydrogels, emphasizing their potential in clinical applications such as hemostasis, chronic wound management, and regenerative medicine. The paper aims to inspire further research to overcome current challenges and advance the use of soft matter in healthcare.