Keloid Formation and Skin Complications in Patients Treated With Isotretinoin and Undergoing Skin-Related Procedures

The study reviewed 34 studies involving 1,563 patients to assess the safety of performing skin procedures during or soon after isotretinoin treatment for acne vulgaris. It found insufficient evidence to support delaying procedures like laser hair removal, fractional lasers, chemical peels, dermabrasion, and microneedling during isotretinoin use, though more aggressive procedures like fully ablative lasers and mechanical dermabrasion are not recommended. Common side effects included transient erythema, dryness, and hyperpigmentation, with keloid formation linked more to procedures than isotretinoin. The study suggests lower isotretinoin doses for aggressive treatments and emphasizes the need for further research to determine optimal timing and safety. Overall, nonablative lasers and isotretinoin can be used simultaneously, improving acne and scar outcomes without significant side effects.