Expression Patterns of Keratin Intermediate Filament and Keratin Associated Protein Genes in Wool Follicles

March 2009 in “ Differentiation ”

Zhidong Yu, Steven W. Gordon, A. J. Nixon, C. Simon Bawden, Michael A. Rogers, Janet E. Wildermoth, Nauman J. Maqbool, A.J. Pearson

keratin intermediate filaments keratin-associated proteins KRT27 KRT35 KRT38 KRTAP4-3 wool follicles gene expression follicle growth cycle primary follicles secondary follicles keratin KIFs KAPs

TLDR Gene expression in wool follicles changes with growth cycles, offering insights into wool and human hair growth.

This study characterized the expression patterns of novel keratin intermediate filaments (KIFs) and keratin-associated proteins (KAPs) in wool follicles of New Zealand Wiltshire sheep, identifying full coding sequences for three new KIFs (KRT27, KRT35, and KRT38) and one KAP (KRTAP4-3). The research found that gene expression varied with the wool follicle growth cycle, becoming more restricted during regression and ceasing during dormancy, with differences noted between primary and secondary follicles. These findings provided insights into the molecular mechanisms of wool growth and structure, with potential implications for understanding similar processes in human hair.

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Semantic ratio: 80%