The Roles of Keratinocytes in the Initiation, Progression, and Maintenance of Hidradenitis Suppurativa

Hidradenitis suppurativa (HS) is an autoinflammatory skin disease characterized by painful nodules and abscesses, primarily affecting areas like the axillae and groin. The disease is believed to originate from a defect in the hair follicle, leading to inflammation. This review highlights the role of keratinocytes (KCs) in HS, focusing on their genetic and metabolic abnormalities that contribute to the disease. KCs are implicated in producing proinflammatory cytokines and attracting immune cells, which exacerbate the condition. The review also discusses the heterogeneity of KCs in draining tunnels and their impact on disease progression.