TLDR CAP1 decreases the expression of a hair-related protein in young Tan sheep's skin.
The study investigated the expression of the KRT83 gene, crucial for hair development, in Chinese Tan sheep, comparing 1-month-old lambs with curly fleece to 48-month-old adults with less curly fleece. KRT83 was highly expressed in the skin of lambs but significantly reduced in adults. The core promoter region of KRT83 was identified, and CAP1 was found to bind to this region, negatively regulating KRT83 expression. Overexpression of CAP1 repressed KRT83 promoter activity, suggesting CAP1's role in the phenotypic change of fleece as the sheep age. The study provided insights into the transcriptional regulation of KRT83 and its impact on fleece characteristics.
18 citations
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January 2015 in “Experimental Dermatology” New mutations in KRT83 and KRT86 are linked to the hair disorder monilethrix.
28 citations
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March 2014 in “Biological reviews/Biological reviews of the Cambridge Philosophical Society” The document concludes that hair curvature can be explained by the growth patterns caused by the shape and separation of cells in the hair follicle and is affected by specific molecular pathways.
15 citations
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June 2012 in “British Journal of Dermatology” A new mutation in the KRT86 gene causes a hair disorder with variable expression.
83 citations
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May 2011 in “Experimental Dermatology” Sheep have 17 keratin genes, similar to humans, but with different expression patterns affecting wool and hair.
28 citations
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February 2010 in “Experimental Dermatology” The frizzy mouse and hairless rat mutations are due to changes in the Prss8 gene.
35 citations
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April 2008 in “Journal of Biological Chemistry” Hirosaki hairless rats lack hair due to missing DNA with key keratin genes.
254 citations
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January 2007 in “Chemical Society Reviews” Hair is a complex protein fiber with unique properties useful for developing hair products.
