Ku80 as a Novel Receptor for Thymosin Beta 4 That Mediates Its Intracellular Activity Different from G-Actin Sequestering

    November 2007 in “ Journal of Biological Chemistry ”
    Radosław Bednarek, Joanna Boncela, Katarzyna Smolarczyk, Aleksandra Cierniewska‐Cieslak, Elżbieta Wyroba, Czesław S. Cierniewski
    TLDR Ku80 is a key receptor for Thymosin β4, affecting cell migration and wound healing.
    The study revealed that Ku80 served as a novel receptor for Thymosin β4 (Tβ4) in endothelial cells, mediating its intracellular activity and influencing the expression of the PAI-1 gene, which is crucial for cell migration and wound healing. The interaction between Tβ4 and Ku80 was essential for this process, as mutations affecting their binding significantly altered PAI-1 expression. This indicated that Ku80 played a key role in the intracellular signaling pathway of Tβ4, independent of its known function of G-actin sequestering.
    Discuss this study in the Community →

    Research cited in this study

    1 / 1 results