Ku80 as a Novel Receptor for Thymosin Beta 4 That Mediates Its Intracellular Activity Different from G-Actin Sequestering

The study demonstrated that Ku80 served as a novel receptor for Thymosin β4 (Tβ4) in endothelial cells, mediating its intracellular activity distinct from G-actin sequestering. Increased intracellular expression of Tβ4 was necessary to induce plasminogen activator inhibitor type 1 (PAI-1) gene expression. The interaction between Tβ4 and Ku80 was confirmed, and down-regulation of Ku80 significantly reduced PAI-1 expression, indicating Ku80's critical role in Tβ4's signaling pathway. The research highlighted the importance of Ku80 in Tβ4-induced signaling pathways, although the exact mechanism remained unclear.