Leydig cell ovarian tumour: a rare cause of hyperandrogenism
April 2026
in “
BMJ Case Reports
”
TLDR Leydig cell tumors can cause high testosterone in women and are treated by removing the ovaries.
A postmenopausal woman with androgenic alopecia and elevated testosterone levels was found to have a benign Leydig cell tumour in her right ovary and Leydig cell hyperplasia in her left ovary. After undergoing bilateral salpingo-oophorectomy, her testosterone levels improved significantly. This case underscores the complexity of diagnosing hyperandrogenism in postmenopausal women, with ovarian and adrenal origins being the most common causes. Leydig cell tumours, though rare, are benign and androgen-secreting, and the preferred treatment is bilateral salpingo-oophorectomy, which is typically curative.