Lgr5 Stem Cells and Potential Treatments for Hair Loss
January 2026
in “
Theoretical and Natural Science
”
Lgr5+ hair follicle stem cells hair follicle regeneration Wnt/-catenin pathway Shh pathway BMP pathway Notch pathway EDA/EDAR/NF-B pathway Wnt signaling peptide-based therapies small molecule modulators stem cell-based regenerative therapies Lgr5 stem cells Wnt pathway Sonic Hedgehog pathway Bone Morphogenetic Protein pathway Ectodysplasin A receptor pathway stem cell therapies
TLDR Targeting Lgr5+ stem cells and Wnt signaling may effectively treat hair loss.
The paper discusses the role of Lgr5+ hair follicle stem cells (HFSCs) in hair follicle regeneration, emphasizing their importance in hair follicle cycling and homeostasis. It highlights the Wnt/-catenin pathway as crucial for regulating stem cell activity and hair follicle development, with interactions involving other pathways like Shh, BMP, Notch, and EDA/EDAR/NF-B. Dysregulation of Wnt signaling can lead to hair loss or abnormal growths. The paper explores potential treatments targeting Wnt signaling and Lgr5+ HFSCs, including peptide-based therapies, small molecule modulators, physical therapy adjuncts, and stem cell-based regenerative therapies, stressing the need for precise modulation to treat hair loss effectively.
