Lgr6+ cells in the biological system during homeostasis and injury

September 2025 in “ Genes & Diseases ”

Han Li, Xiaoqi Guan, Yu Wang, Hai-dong Guo

TLDR Lgr6+ cells are important for tissue repair and could be a target for treating cancer and other diseases.

Lgr6, a member of the G protein-coupled receptor family, is crucial in cellular signal transduction and is involved in various diseases such as diabetic cardiomyopathy, bone regeneration defects, and skin injury repair. This study examines Lgr6<sup>+</sup> cells' distribution and functions during homeostasis and injury, finding their expression in skin, mammary glands, kidneys, and intestines, which is essential for development and tissue repair. Abnormal Lgr6 expression is linked to systemic diseases, particularly tumors, making it a promising therapeutic target for cancer and other diseases, affecting their onset, progression, and treatment.

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Research cited in this study

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research Compartmentalized Epidermal Activation of β-Catenin Differentially Affects Lineage Reprogramming and Underlies Tumor Heterogeneity

54 citations , January 2016 in “Cell reports”

Activating β-catenin in different skin stem cells causes various types of hair growth and skin tumors.

Stimulation of the Follicular Bulge LGR5+ and LGR6+ Stem Cells with the Gut-Derived Human Alpha Defensin 5 Results in Decreased Bacterial Presence, Enhanced Wound Healing, and Hair Growth from Tissues Devoid of Adnexal Structures

research Stimulation of the Follicular Bulge LGR5+ and LGR6+ Stem Cells with the Gut-Derived Human Alpha Defensin 5 Results in Decreased Bacterial Presence, Enhanced Wound Healing, and Hair Growth from Tissues Devoid of Adnexal Structures

39 citations , October 2013 in “Plastic and Reconstructive Surgery”

Human alpha defensin 5 helps heal wounds, reduce bacteria, and grow hair on burned skin.

research Wnt-Dependent De Novo Hair Follicle Regeneration in Adult Mouse Skin After Wounding

829 citations , May 2007 in “Nature”

Hair follicles can regrow in wounded adult mouse skin using a process like embryo development.

research Stem Cells in the Hair Follicle Bulge Contribute to Wound Repair but Not to Homeostasis of the Epidermis

1279 citations , November 2005 in “Nature Medicine”

Lgr6+ cells in the biological system during homeostasis and injury

Research cited in this study

research Twist1 Is Required for the Development of UVB-Induced Squamous Cell Carcinoma

research IL-36α Promoted Wound-Induced Hair Follicle Neogenesis via Hair Follicle Stem/Progenitor Cell Proliferation

research NEDD4 and NEDD4L Regulate Wnt Signaling and Intestinal Stem Cell Priming by Degrading LGR5 Receptor

research Distinct Expression Profile of Stem Cell Markers, LGR5 and LGR6, in Basaloid Skin Tumors

research Compartmentalized Epidermal Activation of β-Catenin Differentially Affects Lineage Reprogramming and Underlies Tumor Heterogeneity

research Stimulation of the Follicular Bulge LGR5+ and LGR6+ Stem Cells with the Gut-Derived Human Alpha Defensin 5 Results in Decreased Bacterial Presence, Enhanced Wound Healing, and Hair Growth from Tissues Devoid of Adnexal Structures

research Wnt-Dependent De Novo Hair Follicle Regeneration in Adult Mouse Skin After Wounding

research Stem Cells in the Hair Follicle Bulge Contribute to Wound Repair but Not to Homeostasis of the Epidermis