LHX2: A Transcription Factor in Development, Homeostasis, Repair, and Disease
June 2026
in “
Frontiers in Cell and Developmental Biology
”
TLDR LHX2 is crucial for development, tissue repair, and preventing diseases.
LHX2 is a LIM-homeodomain transcription factor essential for vertebrate development, tissue homeostasis, and injury repair. It is involved in the development of the cerebral cortex, hippocampus, retina, and hair follicles, maintaining quiescence in various stem cells and promoting regeneration after injury. Dysregulation of LHX2 is associated with disorders like neurodevelopmental disorders, liver fibrosis, osteoporosis, and cancers. It influences metabolic-epigenetic circuits and signaling pathways such as PI3K/AKT/mTOR and Wnt/β-catenin. Understanding LHX2-regulated networks could enhance regenerative medicine and precision interventions for developmental disorders.
