Lithium Chloride-Treated Human Umbilical Cord Mesenchymal Stem Cells-Derived Exosomes Promote Hair Growth by Regulating miR-146a-5p-Wnt Pathway

    September 2025 in “ Stem Cells Translational Medicine ”
    Zhao Wang, Zhi Chai, Xuegang Xu, Yongjun Piao, Lin Gong
    TLDR Lithium chloride-treated stem cell exosomes boost hair growth by activating a specific pathway.
    This study demonstrates that exosomes derived from lithium chloride-treated human umbilical cord mesenchymal stem cells significantly promote hair growth by activating the Wnt signaling pathway, particularly through the regulation of miR-146a-5p, which targets SFRP1. Experiments involving six C57BL/6 mice showed that these exosomes accelerate the transition of hair follicles into the anagen phase, enhancing hair coverage. The research identifies miR-146a-5p as a key miRNA that enhances the proliferation and migration of dermal papilla cells, suggesting potential targets for new hair loss treatments. The findings offer a promising alternative to current therapies, although further research is needed for clinical application.
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