TLDR Flutamide rarely causes liver toxicity in prostate cancer patients.
In a study of 1,091 prostate cancer patients treated with flutamide and a LHRH agonist, only four patients (0.36%) experienced significant liver toxicity, with two (0.18%) developing clinical liver disease. The toxicity resolved upon discontinuation of flutamide. The majority of patients had no or only mild and transient liver enzyme elevations. The study concluded that flutamide-induced liver toxicity is rare and recommended monitoring liver function at the start of treatment and after 2 and 4 weeks to quickly identify and manage any potential liver injury.
130 citations
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September 1990 in “Journal of the American Academy of Dermatology” Flutamide effectively reduced excessive hair growth and improved related symptoms in hirsutism patients without significant side effects.
38 citations
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October 1996 in “Dermatologic Clinics” Certain hormone treatments can improve acne and related conditions in women.
32 citations
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November 1996 in “International Journal of Dermatology” Antiandrogens can help treat skin conditions like acne and excessive hair in women when used carefully.
284 citations
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February 2008 in “Pediatrics” Chemicals and body size might change when puberty starts and progresses, but more research is needed to confirm this.
502 citations
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February 2008 in “The Journal of Clinical Endocrinology & Metabolism” Treat significant hirsutism with medication and hair removal; use birth control pills first, adding antiandrogens if needed.
January 2019 in “Oncogen” Triple Hormonal Blockade (ADT3) can effectively manage prostate cancer but requires careful monitoring for heart risks.
