Living microecological hydrogels for wound healing

    May 2023 in “ Science Advances ”
    Guopu Chen, Fengyuan Wang, Xiaoxuan Zhang, Yixuan Shang, Yuanjin Zhao
    TLDR The hydrogel speeds up healing of infected wounds by providing oxygen and fighting bacteria.
    The study introduces a living microecological hydrogel (LMH) designed to enhance chronic wound healing by addressing infections and hypoxia. The hydrogel incorporates functionalized <i>Chlorella</i> and <i>Bacillus subtilis</i>, which work synergistically to deliver continuous oxygen and combat infections. The thermosensitive and adhesive properties of the hydrogel allow it to remain liquid at low temperatures and solidify upon application, adhering tightly to wounds. The <i>Chlorella</i> produces oxygen to alleviate hypoxia and support the growth of <i>B. subtilis</i>, which in turn eliminates pathogenic bacteria. This innovative approach significantly improves the healing of infected diabetic wounds, highlighting its potential for clinical use.
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