TLDR lncRNA MRPS28 regulates hair follicle development in cashmere goats, affecting cashmere quality.
The study explores the role of lncRNA MRPS28 in the development of secondary hair follicles (SHFs) in cashmere goats, which is vital for cashmere quality and yield. Researchers found that lncRNA MRPS28 acts as a sponge for chi-miR-145-5p, reducing its inhibitory effect on the NUAK1 gene. This interaction influences the proliferation and migration of dermal fibroblasts by modulating the cell cycle and apoptosis, thereby affecting SHF morphogenesis. The study highlights the lncRNA MRPS28/chi-miR-145-5p/NUAK1 signaling axis as a key regulatory network, offering potential molecular targets for enhancing cashmere production.
November 2023 in “Animal Bioscience” miR-133a-3p and miR-145-5p help goat hair follicle stem cells differentiate by controlling NANOG and SOX9.
2 citations
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September 2022 in “Frontiers in veterinary science” Certain long non-coding RNAs are important for the growth of hair follicles in Inner Mongolian cashmere goats.
7 citations
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September 2022 in “International journal of molecular sciences” The research found that the molecule lncRNA-H19 helps hair follicle cells grow by affecting certain cell pathways in cashmere goats.
May 2022 in “Frontiers in Cell and Developmental Biology” miR-29a-5p prevents the formation of early hair structures by targeting a gene important for hair growth and is regulated by a complex network involving lncRNA627.1.
22 citations
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April 2020 in “Scientific reports” Changthangi goats have specific genes that help produce Pashmina wool.
11 citations
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March 2020 in “Cellular Signalling” XIST RNA helps regenerate hair follicles by targeting miR-424 and activating hedgehog signaling.
11 citations
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June 2017 in “Asian-Australasian journal of animal sciences” Fox genes are important for hair growth and development in cashmere goats.
127 citations
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March 2016 in “PLoS ONE” Key genes and pathways crucial for hair follicle development in cashmere goats were identified, aiding fleece production improvement.
