Local IL-17 Orchestrates Skin Aging

    January 2022 in “ bioRxiv (Cold Spring Harbor Laboratory) ”
    Paloma Solá, Elisabetta Mereu, Júlia Bonjoch, Marta Casado-Peláez, Oscar Reina, Enrique Blanco, Manel Esteller, Luciano DiCroce, Holger Heyn, Guiomar Solanas, Salvador Aznar Benitah
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    TLDR Blocking IL-17 signaling can delay skin aging and improve skin and hair health.
    The study "Local IL-17 orchestrates skin aging" provides a comprehensive understanding of age-associated changes in all skin cell types, based on deep single-cell RNA-sequencing of the entire dermal compartment. The research reveals a previously unreported skew towards an IL-17–expressing phenotype of Th cells, γδ T cells, and innate lymphoid cells in aged skin. IL-17 signaling, common to many autoimmune and chronic inflammatory diseases, increases with age. The in vivo blockade of IL-17–triggered signaling during the aging process reduces the pro-inflammatory state, affecting immune and non-immune skin cells of both dermis and epidermis. Notably, IL-17 neutralization significantly delays the appearance of age-related traits, such as decreased epidermal thickness, increased cornified layer thickness, and improved hair follicle stem cell activation and hair shaft regeneration. The findings suggest that targeting age-associated increased IL-17 signaling could be a strategy to prevent age-associated skin ailments in the elderly.
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