Long-Lived Proteins and DNA as Candidate Predictive Biomarkers for Tissue-Associated Diseases

This study investigated long-lived proteins (LLPs) in mice using stable isotope labeling from birth to postnatal day 89, identifying 2113 LLPs across ten tissues and plasma. The findings suggest that LLPs, due to their vulnerability to accumulated damage, could be linked to age-related diseases, with plasma LLPs potentially associated with cardiovascular diseases and brain LLPs with neurodegenerative diseases. Additionally, DNA-derived deoxynucleosides correlated with LLPs in the brain, indicating cellular DNA renewal rates. The research highlights the potential of tissue-derived peripheral LLPs as biomarkers for aging and age-related diseases due to their low renewal rate and increased risk of damage.