Leucocyte-Rich Platelet-Rich Plasma Enhances Fibroblast and Extracellular Matrix Activity: Implications in Wound Healing

The study investigated the effects of leucocyte-rich platelet-rich plasma (LR-PRP) on fibroblast activity and extracellular matrix dynamics, which are crucial for wound healing. It found that LR-PRP significantly enhanced fibroblast proliferation and migration, achieving 100% wound closure in 48 hours compared to 60.1% with leucocyte-poor platelet-poor plasma (LP-PPP). The research highlighted the upregulation of genes involved in extracellular matrix remodeling and cell adhesion, suggesting LR-PRP's potential as a complementary treatment for delayed wound healing. However, the study was conducted in vitro and not directly applicable to clinical settings.