Comparative Assessment of Topical Platelet-Rich Plasma and Phenytoin for Diabetic Foot Ulcer Healing in a Rat Model

This study compared the wound-healing efficacy of 1% phenytoin cream and platelet-rich plasma (PRP) gel in a rat model of diabetic foot ulcers. Conducted over 84 days with 20 rats, the study found that both treatments were effective in promoting wound contraction, tissue repair, and re-epithelialization. Although PRP gel showed greater wound contraction and more advanced histological improvements, such as granulation tissue and collagen deposition, the differences between the two treatments were not statistically significant. PRP achieved complete wound closure by day 84, while phenytoin showed near-complete closure. The study suggests that PRP may offer more advanced tissue reconstruction and recommends future research to standardize PRP application protocols.