N6-Methyladenosine (m6A)-CircHECA Facilitates the Differentiation of SHF Stem Cells Into Hair Follicle Lineage Through miR-449a-5p/LEF1 Mediated Wnt/β-Catenin Pathway in Cashmere Goats

The study explores how N6-methyladenosine (m6A)-modified circular RNA, circHECA, aids in the differentiation of secondary hair follicle (SHF) stem cells into hair follicle lineage in cashmere goats. It reveals that circHECA operates through the miR-449a-5p/LEF1 mediated Wnt/β-catenin signaling pathway, which is essential for hair follicle development and regeneration. These findings suggest that m6A-circHECA could be targeted to enhance hair growth, offering insights into the molecular mechanisms of hair follicle differentiation and potential applications for boosting cashmere production.