m6A Methylation Analysis of Differentially Expressed Genes in Skin Tissues of Coarse and Fine Type Liaoning Cashmere Goats

January 2020 in “ Frontiers in Genetics ”

Yanru Wang, Yuanyuan Zheng, Dan Guo, Xinghui Zhang, Suling Guo, Taiyu Hui, Yue Chang, Jiaming Sun, Suping Guo, Zhixian Bai, Weidong Cai, Xinjiang Zhang, Yixing Fan, Zeying Wang, Wenlin Bai

TLDR m6A methylation affects cashmere fiber growth in goats.

The study investigated m6A methylation in cashmere goats to understand its role in fiber growth. Using MeRIP-seq and RNA-seq, researchers identified 9,085 differentially methylated m6A sites, with 7,170 upregulated and 1,915 downregulated. They compared fine-type and coarse-type Liaoning cashmere goats, finding 1,170 differentially expressed genes. Validation through qRT-PCR focused on 19 genes, and GO enrichment analysis indicated involvement in keratin and intermediate filaments. These results provided a theoretical basis for future research on m6A modification's function in cashmere fiber growth.

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