M6a Methylation Analysis of Differentially Expressed Genes in Skin Tissues of Coarse and Fine Type Liaoning Cashmere Goats

January 2020 in “ Frontiers in Genetics ”

Yanru Wang, Yuanyuan Zheng, Dan Guo, Xinghui Zhang, Suling Guo, Taiyu Hui, Yue Chang, Jiaming Sun, Suping Guo, Zhixian Bai, Weidong Cai, Xinjiang Zhang, Yixing Fan, Zeying Wang, Wenlin Bai

m6A methylation differentially expressed genes KRT26 KRT32 KRT82 hair follicle development cashmere fiber growth

TLDR m6A methylation affects cashmere fiber growth in goats.

The study analyzed m6A methylation in the skin tissues of fine and coarse type Liaoning cashmere goats to understand its role in cashmere fiber growth. Researchers identified 9,085 differentially methylated m6A sites and 1,170 differentially expressed genes, with key genes like KRT26, KRT32, and KRT82 potentially crucial for cashmere growth and fineness. The study linked m6A modifications to pathways involved in hair follicle development, providing a theoretical basis for future research on m6A modification's function in cashmere fiber growth.

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