Malignant Melanoma and Its Stromal Nonimmune Microecosystem
January 2012
in “
Journal of Oncology
”
cutaneous malignant melanoma stromal nonimmune microecosystem dermal extracellular matrix stromal cells Factor XIIIa CD34 versican α (IV) collagen chains neoangiogenesis metastatic spread CMM stem cells HOX gene expression sentinel lymph nodes melanoma ECM collagen angiogenesis metastasis stem cells lymph nodes
TLDR The surrounding tissue plays a crucial role in the growth and spread of skin cancer.
The document explored the interactions between cutaneous malignant melanoma (CMM) cells and their stromal microenvironment, highlighting the active role of stromal cells in tumor progression and metastasis. It emphasized that stromal changes, including the secretion of metalloproteinases and growth factors, contribute to CMM cell growth and mobility. Immunohistochemistry identified significant molecules like Factor XIIIa and CD34, which influence CMM cell migration. The study suggested that stromal cells are not passive but actively contribute to CMM progression, with potential diagnostic and prognostic implications, and called for further research to understand these interactions.
