Pentacyclic Triterpenoid Maslinic Acid Promotes Hair Growth Comparable To Minoxidil: A New Insight On The Potential Involvement Of Cilia Activity

    January 2025 in “ Institutional Repositories DataBase (IRDB) ”
    Oliva Mizushima Aprill Kee, Bouhoute Meryem, Bejaoui Meriem, Ferdousi Farhana, Nakajima Mitsutoshi, Isoda Hiroko
    The study investigates the effects of maslinic acid, a component of olive extracts, on hair growth, finding it comparable to minoxidil in promoting hair growth in mice. Maslinic acid accelerates anagen induction and increases protein levels of CTNNB1 and VEGF, while upregulating trichogenic genes like CTNNB1, ALPL, and FGF1. It activates pathways crucial for hair growth, including Wnt, Notch, MAPK, and angiogenesis. The study also highlights a potential link between hair growth and cilia activity, as maslinic acid upregulates the ciliogenesis-promoting gene Iqcb1, and inhibiting cilia activity downregulates CTNNB1. This suggests maslinic acid stimulates hair growth through the Wnt/-catenin pathway and ciliary gene activity.
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