Mast-Cell Driven Dermal White Adipose Tissue Remodeling Amplifies Inflammation and Fibrosis in Atopic Dermatitis

    January 2026
    Lingjuan Zhang, Shujun Heng, Zhuolin Guo, J. Li, Sheng Lin, Yuanyuan Wang, Youxi Liu, Zhichong Tang, J. Li, Huang Jm, Yuling Shi
    TLDR Adipocytes in atopic dermatitis skin change and worsen inflammation and fibrosis.
    This study investigates the role of dermal white adipose tissue (dWAT) in atopic dermatitis (AD) using a mouse model. It reveals that dWAT undergoes lipolysis and fibrosis alongside mast-cell (MC) accumulation. Adipocytes lose lipids and transform into inflammatory preadipocytes, secreting chemokines that recruit MCs, creating a self-amplifying inflammatory-fibrotic loop. Neutralizing these chemokines or depleting MCs disrupts this loop. Human AD skin shows similar adipocyte changes, suggesting a new pathway where adipocytes convert to fibroblasts, promoting MC recruitment and fibrosis. This offers a potential therapeutic target to block adipocyte dedifferentiation and its signals to reduce inflammation and fibrosis in AD.
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