Appendix A: Mathematical Model AL/RC/ASE. Functional Androgen Axis (FOA) - Operational Version v1.2
April 2026
in “
Zenodo (CERN European Organization for Nuclear Research)
”
TLDR The model improves understanding of androgen interactions by focusing on signal intensity and system capacity.
Dodatek A operationalizes the Functional Androgen Axis (FOA) framework by defining three system-level indices: Androgen Load (ALi), Receptor Capacity (RCi), and Output Index (Oi), along with the Androgen Signal Efficiency (ASE_adj). Version v1.2 introduces five methodological improvements, including trapezoidal threshold functions for variables with U-shaped response characteristics, unequal weighting in the hematologic domain, a DHT proxy for analysis without direct measurement, a verification protocol for collinearity, and separation of measurement instruments to avoid double-counting. The model uses proxy markers and phenotypic measures, with documented limitations and assumptions, and serves as an operational complement to the base FOA publication.
