TLDR tSVF is effective for treating inflammation-related conditions, with centrifugation being the best method for isolation.
This scoping review evaluates mechanical fractionation methods for obtaining stromal vascular fraction (tSVF) from adipose tissue, used in regenerative therapies. It includes data from 1,465 patients and 410 animals, finding that tSVF is more effective in treating conditions with high proinflammatory characteristics, such as osteoarthritis and wound healing, than in skin rejuvenation. Centrifugation is identified as the most effective method for tSVF isolation. The review highlights the need for standardized procedures and further research to optimize tSVF isolation techniques, noting the variability in outcomes and the absence of a superior method due to differing study designs and endpoints.
4 citations
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September 2020 in “Annals of Translational Medicine” Concentrated nanofat helps mice grow hair by activating skin cells and may be used to treat hair loss.
25 citations
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May 2020 in “Aesthetic Surgery Journal” The regenerative solution, tSVF, is a safe and effective treatment for various conditions like aged skin, scars, wounds, and more, but more research is needed to find the best way to use it.
40 citations
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March 2018 in “Aesthetic Surgery Journal” New treatment combining PRP and SVF increases hair density in 6-12 weeks for androgenetic alopecia patients.
62 citations
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October 2017 in “JAMA facial plastic surgery” Condensed nanofat with fat grafts effectively improves atrophic facial scars.
25 citations
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May 2020 in “Aesthetic Surgery Journal” The regenerative solution, tSVF, is a safe and effective treatment for various conditions like aged skin, scars, wounds, and more, but more research is needed to find the best way to use it.
2 citations
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March 2019 in “Plastic and Reconstructive Surgery” The letter suggests that a modified fat processing technique may increase regenerative cells but calls for more trials to confirm its effectiveness for skin and hair treatments.
7 citations
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June 2022 in “Frontiers in Medicine” ADSC-derived extracellular vesicles show promise for skin and hair regeneration and wound healing.
13 citations
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July 2020 in “Stem Cell Research & Therapy” Young donor, early passage stem cells have the highest stemness.
November 2025 in “International Journal of Molecular Sciences” PRP shows promise in healing and regeneration but needs standardized protocols for consistent results.
