TLDR Melanocyte progenitor cells are found in human fat tissue and can become mature melanocytes, which may help treat skin issues.
The study demonstrated that melanocyte progenitor cells were present in human subcutaneous adipose tissue. Researchers found that undifferentiated adipose-derived stem cells (ADSCs) expressed melanocytic markers such as HMB45 and MITF, with increased expression during differentiation in melanocyte-specific culture medium. Additional markers like Melan A, MATP, and tyrosinase were also detected. In a 3D epidermal culture system, differentiated ADSCs localized in the basal layer and expressed tyrosinase and HMB45, with melanin deposits induced by UVB irradiation. These findings suggested that these progenitor cells could potentially differentiate into mature melanocytes, offering future applications in treating skin diseases and skin rejuvenation.
24 citations
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March 2018 in “Pigment Cell & Melanoma Research” The environment around melanocyte stem cells is key for hair regeneration and color, with certain injuries affecting hair color and potential treatments for pigmentation disorders.
829 citations
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May 2007 in “Nature” Hair follicles can regrow in wounded adult mouse skin using a process like embryo development.
18 citations
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October 2022 in “Biomedicines” Regenerative treatments for vitiligo show promise but need more research for long-term safety and effectiveness.
Skin stem cells are crucial for maintaining and repairing skin, with potential for treating skin disorders and improving wound healing.
132 citations
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January 2017 in “International Journal of Molecular Sciences” Fat-derived stem cells show promise for skin repair and reducing aging signs but need more research for consistent results.
45 citations
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August 2018 in “Stem Cells International” Stem cells, especially from fat tissue and Wharton's jelly, can potentially regenerate hair follicles and treat hair loss, but more research is needed to perfect the treatment.
19 citations
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January 2017 in “Stem Cells International” Adipose-derived stem cells show promise in treating skin conditions like vitiligo, alopecia, and nonhealing wounds.
