A Short Report on Melanocyte/Melanoma Culture, Senescence, and Reproducibility

    March 2026 in “ Pigment Cell & Melanoma Research ”
    Lionel Larue, ESPCR Working Group, Duarte C. Barral, Veronique Delmas, Sara Egea‐Rodriguez, Daniel Aldea, Heather Etchevers, Marie‐Dominique Galibert, Robert N. Kelsh, Luisa Lanfrancone, Michele Madigan, Pedro Moura‐Alves, Richard M. White, Anja Bosserhoff
    TLDR Clear documentation and shared best practices are essential for improving research consistency in pigment cells.
    The report addresses the challenges in culturing melanocytes and melanoma cells, emphasizing the need for standardization and reproducibility in research. It identifies key issues such as variability in cell culture conditions, genetic and phenotypic drift, and the impact of donor factors like age and tissue source on experimental outcomes. Recommendations include rigorous documentation, quality control measures, and the adoption of alternative models like 3D cultures. The report also highlights species-specific differences in melanocyte biology and the importance of standardized protocols to improve study reliability. Community engagement and transparent reporting are encouraged to enhance scientific reproducibility.
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