Cyclic Nucleotides and the Mediation of Melatonin-Induced Inhibition of Melanogenesis in Mammals

    January 1981 in “ Elsevier eBooks ”
    Brian Weatherhead, Ann Logan
    TLDR Melatonin stops melanin production after tyrosinase action, with cyclic GMP mimicking this effect.
    The document discussed how melatonin inhibited melanogenesis in hair follicle cultures in vitro without affecting tyrosinase activity, suggesting the inhibition occurred at a post-tyrosinase step in the melanin biosynthetic pathway. It was noted that cyclic GMP mimicked melatonin's effects and could override the stimulatory effects of cyclic AMP on melanogenesis.
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