Effect of Metformin and Myo-Inositol in Patients with Polycystic Ovary Syndrome

January 2023 in “ Al-Azhar International Medical Journal /Al-Azhar International Medical Journal ”

Hanaa Fathi Abo Ria, Hanan Abd El-Monem Mohammed, Hoda Ismail Sayed Hemida

metformin myo-inositol Polycystic Ovary Syndrome PCOS

TLDR Combining metformin with myo-inositol is more effective for treating PCOS than metformin alone.

The study investigated the effects of combining metformin and myo-inositol in 100 women with Polycystic Ovary Syndrome (PCOS), divided into two groups. Group I received both metformin and myo-inositol, while Group II received only metformin. After 3 months, results showed that the combination treatment led to a statistically significant improvement in normal ovarian size and higher pregnancy rates compared to metformin alone. The study concluded that the combination of metformin with myo-inositol was more effective in treating PCOS than metformin alone.

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Research cited in this study

1 / 1 results

research Prevalence of Hyperandrogenemia in Polycystic Ovary Syndrome Diagnosed by the National Institutes of Health 1990 Criteria

118 citations , February 2009 in “Fertility and Sterility”

Most women with PCOS have high levels of male hormones, and free testosterone is the best marker for this.

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Combining therapies like scyllo-inositol, alpha-ketoglutarate, and autophagy-inducing supplements may enhance hair growth and prevent hair loss. Reporting individual results can accelerate progress in hair loss treatments.

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in Research/Science 12 upvotes 5 years ago

The conversation discusses the potential of topical rapamycin, metformin, and alpha-ketoglutarate (a-KG) for hair growth, with skepticism expressed about their effectiveness based on personal experience and existing use. It also mentions AICAR, known as cardarine or GW, which is not suitable for long-term use due to cancer risks in animal studies and its similarity to metformin.

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Topical Metformin shows potential for regenerating hair follicles and minimizing scarring in hair transplant donor areas, similar to Verteporfin but without its side effects. The discussion suggests considering Metformin for post-hair transplant care, though more human trials are needed.

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in Finasteride/Dutasteride 1 upvotes 2 years ago

The conversation is about whether it's safe to take Metformin for weight loss and Finasteride together, with the concern that Finasteride is not commonly used for hair loss treatment in the user's location, and their doctor is not knowledgeable about it.

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2 upvotes 7 years ago

Rapamycin and metformin may have hair regeneration properties. Specific treatments discussed include Minoxidil, finasteride, and RU58841.

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Metformin: An Old Medication of New Fashion: Evolving New Molecular Mechanisms and Clinical Implications in Polycystic Ovary Syndrome

research Metformin: An Old Medication of New Fashion: Evolving New Molecular Mechanisms and Clinical Implications in Polycystic Ovary Syndrome

200 citations , October 2009 in “European journal of endocrinology”

Metformin helps manage polycystic ovary syndrome by improving insulin resistance and ovulation, but more research is needed on its full effects.