Effect of Methanol Extract of Etlingera Alba (Blume) A. D. Poulsen Stems on Caspase-3 Gene Suppression as an Apoptosis Marker in T47D Breast Cancer Cell Line In Vitro

    June 2025 in “ Jurnal Mandala Pharmacon Indonesia ”
    Fitria Nurcahyani, Adryan Fristiohady, Sahidin Sahidin, Wahyuni Wahyuni, Agung Wibawa Mahatva Yodha, Dian Munasari Solo, Muhammad Arba, Irnawati Irnawati
    TLDR Etlingera alba extract may help treat breast cancer with fewer side effects.
    The study investigates the potential of methanol extract from the stem of Etlingera alba to suppress the expression of the apoptosis marker gene Caspase-3 in T47D breast cancer cells. Using RT-PCR, the research tested three concentrations of the extract: 50 ppm, 100 ppm, and 200 ppm. Results showed that the 100 ppm concentration was most effective, reducing gene expression by 1.859 times compared to DMSO 2%. This suggests that E. alba extract could be a promising alternative cancer treatment with fewer side effects than traditional chemotherapy.
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